This antidepressive effect was similar to that of the conventional antidepressant, the St . Johns wort plant.
The antidepressive effect of sleep deprivation (SD) in depressed patients disappears after sleep of the recovery night and after early morning naps.
Amitriptyline is utilized at much lower dose for TTH than that necessary to obtain an antidepressive effect.
TCAs may improve sleep disturbances and, in higher doses, have an antidepressive effect.
Melatonin is a regulatory circadian hormone having, among others, a hypnotic and an antidepressive effect.
However, one conclusion remains clear, given the absence of positive antidepressive effects seen in this study, one can conclude that the beneficial results (pain, function) noted in this study could not be explained by the antidepressive effect of SAMe.
25 27 Melatonin has a possible antidepressive effect 28 34 probably based on its effect on the central circadian regulation 35 and an effect on improving cognitive function.
NPY is a hormone that has been reported to have a soothing, anxiolytic as well as antidepressive effect in the central nervous system [ 35].
These data suggest that 5HT6 antagonists, at doses corresponding to those that occupy central 5-HT6 recouldrs, could have an antidepressive effect in humans.
This outcome might have had a specific antidepressive effect, which could explain the significantly greater reduction of depressive symptoms in this group.
