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This apparent discrepancy with our data can be explained by the fact that HIGM2 patients have relatively mild and variable clinical phenotypes, possibly due to the contribution of genetic and environmental factors [7], [41], [43].
For these reasons, the effect of nutrient limitation on both proliferation inhibition and increasing recombinant protein secretion can be mild and variable.
The phenotype of macroH2A1 knock out (KO) mice consists of mild and variable derangements in systemic and/or hepatic glucose and lipid metabolism, depending on the strain [ 12, 13].
18 A 2011 review of the current evidence concludes: " the mild and variable nature of any IOP decrease from lens extraction suggests a marginal benefit only in milder forms of POAG.
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Recently, two homozygous missense mutations in MRAP have also been reported that are associated with a milder and variable phenotype (4).
It's milder and more variable and more complicated.
Both tb233c and tk256a (missense mutations) showed a milder and more variable ear swelling than the fr24 allele, which has a truncating mutation (Figs 1, 5, 8).
Line v15975 resulted in the strongest migration defects (14% of stage 10 egg chambers), whereas line v36111 had milder and more variable migration defects.
In four independent experiments, N4-KD cellalinesl lineshoweded a consistently pronounced TER delay, whereas N1-KD clonal cell lines showed a milder and more variable TER delay.
N549K homozygotes display comparable deficits in postnatal development and cerebellar volume to R552H and S321X homozygotes, but symptoms are milder and show variable expressivity, with prolonged survival (3 5 months).
Influenza C was excluded because of milder and more variable symptoms compared with influenza A and B as well as different type of seasonal pattern which indicates different environmental causes.
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