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Side-effects were rare, mild and reversible on withdrawal of treatment.
Nonetheless, although the CAR also engages mouse αvβ6, mild and reversible toxicity was only observed when supra-therapeutic doses of CAR T cells were administered parenterally.
Post-operative complications were mild and reversible.
CMS-induced nephrotoxicity is mostly mild and reversible.
The toxicities were mild and reversible, and grade 3 fatigue occurred in only one patient.
Nephrotoxic effects were mild and reversible, and no patient required renal replacement therapy.
Similar(12)
In most cases, the symptoms are mild, manageable, and reversible, but some patients have died of treatment side effects.
In our case, the main toxicities reported were mild neutropenia and reversible hyper-transaminasemia, in agreement with the safety profile of trabectedin.
20 Pooled analysis in osteoporotic patients treated with strontium ranelate showed that increases were mainly mild, transient and reversible 22; they were not associated with any clinical muscular symptoms.
There was significant variability in the ratings of the relative importance of all adverse events, except those that were mild and easily reversible.
Mucositis and gastrointestinal toxicity (i.e. diarrhoea and nausea/vomiting) were the most relevant and frequently observed grade I/II toxicities; they were generally mild and rapidly reversible.
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