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Furthermore, NAC treatment of wild-type and Zfp277−/− MEFs significantly repressed the expression of p16Ink4a and p19Arf (Figure 3C) and extended the cells' life span, although NAC itself had a mild adverse effect on proliferation as evident from the growth retardation of Zfp277−/− MEFs at early passages (Figure 3D).
In crosses between heterozygous mice, the occurrences of Ing2+/+, Ing2+/− and Ing2−/− genotypes were 27% (154 out of 570), 56% (319 out of 570) and 17% 977 out of 570), respectively, showing a slight deviation from the expected Mendelian distribution and indicating that Ing2 deficiency may have a mild adverse effect on embryonic or prenatal development.
Mild adverse effect Injury or complication that causes none of the above.
It has a relatively mild adverse effect profile, with no risk of the tyramine ('cheese') reaction at normal therapeutic doses.
This indicates a mild adverse effect of LOH events on somatic tissues that sustain a high expression of tissue-specific genes, which allow a high-level of LOH.
The LOH event in old-aged patients may exert a mild adverse effect at a late adaptation stage of newly fixed stem cells that establish a high expression of several stomach-specific genes and the down-regulation of housekeeping genes.
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"Imagine you have a drug where mild adverse effects are documented and hopefully rare adverse effects are being reported in case reports," said Ernst.
"In addition to these fairly mild adverse effects, which basically are pain at the site of manipulation and referred pain sometimes, which only lasts one or two days, we have about 500-700 cases of severe complications being reported".
Five patients suffered mild adverse effects (moon face and hirsutism) between week 4 and week 6 of treatment, which were speedily reversed by reducing the frequency of mouthwash.
"In addition to these fairly mild adverse effects, which basically are pain at the site of manipulation and referred pain sometimes, which only lasts one or two days, we have about 500-700 cases of severe complications being reported". With extreme chiropractic movement of the neck, an artery can disintegrate and lead to a stroke, an outcome that is well-documented in medical literature.
Richards and Marley34 reported a case of intercurrent illness and discomfort in a placebo group, whereas Dong43 reported mild adverse effects, such as dry mouth, headaches, sleepiness, hypertension, palpitations and dizziness, up to 16.7% in the acupuncture group, compared with 42.9% in a group of receiving medication.
More suggestions(15)
benign adverse effect
mild beneficial effect
mild estrogenic effect
mild preventive effect
mild biomass effect
mild mass effect
mild cytotoxic effect
mild Tyndall effect
mild protective effect
mild hallucinogenic effect
mild adverse reaction
mild inhibitory effect
mild stimulatory effect
mild negative effect
mild sedative effect
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