The proliferative and migratory potential and the differentiation capacity of PDLSCs decreased as age increased (p < 0.05).
Moreover, silencing of MLK4 expression significantly reduced the migratory potential and invasiveness of breast cancer cells as well as the number of spheroids formed in 3D cultures.
Collectively, our data indicate that MLK4 contributes to the acquisition of the mesenchymal phenotype and increased migratory potential of breast cancer cells through NF-κB-dependent mechanism.
These findings suggest that higher grade gliomas might arise from less differentiated neuroepithelial cells in the subventricular zone that possess greater migratory potential.
Expression of integrin subunit α6 has been linked to the acquisition of migratory potential in a wide variety of cell types in both pathological and physiological capacities.
In any case, RMS cell lines, which are endowed with migratory potential, are a convenient model for studying cancer metastasis.
Introduction of a small interfering RNA directed to ERRalpha into the highly aggressive breast carcinoma MDA-MB-231 cell line dramatically reduced the migratory potential of these cells.
In addition to chemosensitization, telomere shortening affected another feature of the cancer cell; its migratory potential.
Mutation of these sites increases a cell's migratory potential suggesting that adhesion strength is reduced[28].
Other studies have linked p53 to the control of the migratory potential of various cell types, including macrophages [62], [63].
The wound assay is frequently used to assess the effects of tested compounds on the migratory potential of adherent cells.
