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Since migration is an essential step in invasion and metastasis, in the present study we defined the expression of EP receptors and their roles in migratory function of breast cancer cells of murine (C3L5) and human (MDA-MB-231 and MCF-7) origin.
The migratory function of ECFCs was evaluated by a modified Boyden chamber assay (Transwell, Costar) [ 20].
To evaluate the effect of rivaroxaban on EPCs, the scratch test for migratory function of EPCs was performed.
Given the altered migratory function of SSc monocytes, we evaluated whether their phenotype might also be altered.
The migratory function of EPCs was evaluated using a modified Boyden chamber (Transwell, Corning Inc., MA, USA) assay.
The migratory function of EPCs was evaluated by a modified Boyden chamber (Costar, Cambridge, MA, USA) assay.
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However, it has been suggested that lipid emulsions of TPN may impair host defense, and in particular the bactericidal and migratory functions of the neutrophil polymorhonuclear (PMN) granulocyte in infants receiving TPN [ 7, 51, 60, 67- 69].
This pro-migratory function of KARS suggests a possible role in tumour cell metastasis.
By knocking down FOSL1, we could demonstrate a pro-proliferative and pro-migratory function of this protein in melanoma cell lines.
Overall, the data suggest that the regulation of transcriptional activity of the migration-associated genes plays a significant role in the anti-migratory function of the full-length membrane PTK7.
Moreover, the pro-migratory function of endothelial ADAM17 might not be limited to neutrophils, but might also account for macrophages even in the absence of inflammation as indicated by the finding that the basal number of macrophages in the lungs was reduced in Tie2- adam17−/− mice.
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