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Recently, the proliferative and migratory function in EPCs in diabetic patients has been report to be reduced [ 51].
To overcome the dysfunction, inhibition of NADPH oxidase was reported to restore NO availability and migratory function in diabetic CD34 cells [ 53].
We assessed the correlation of NAMPT levels with cardiovascular variables (random and 24 h blood pressure), functional variables of early vascular impairment (IMT, endothelial function), and regenerative capacity (EPC count and migratory function) in our Atherobesity Childhood cohort.
Considering Ret and its migratory function in developmental processes (Schuchardt et al, 1994) and in cancer (Ito et al, 2005; Morandi et al, 2011), a major goal of our work was to study the role of Ret in a metastatic breast cancer model.
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However, little is known about whether SOCS3 could regulate PYK2 pro-migratory function in lung cancer.
On one side, XIAP was reported to exert a pro-migratory function in endothelial cells, to be required for cell motility by regulating actin polymerization and to cooperate with survivin to foster cell motility and invasion.
Instead, it is possible that K6 regulates a migratory function required in progenitor cells so as to permit their dispersal throughout the mammary gland.
IAPs were shown to exhibit both pro- and anti-migratory functions in tumor cells, which have been discussed below.
To investigate the effects of IFR radiation on EPCs, we used both scratch test and modified Boyden chamber assay to assess the migratory function of EPCs in high glucose conditions.
Since migration is an essential step in invasion and metastasis, in the present study we defined the expression of EP receptors and their roles in migratory function of breast cancer cells of murine (C3L5) and human (MDA-MB-231 and MCF-7) origin.
Monocytes were isolated from whole blood of subjects and migratory function was assessed by in vitro chemotaxis assay comparing radioactively labeled and non-labeled cells.
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