Sentence examples for migratory defects observed from inspiring English sources

The failure of preplate neurons to polarize in the absence of RELN or SFK signaling could be a consequence of the defects in radial glial morphology previously described in reeler or a secondary consequence of the migratory defects observed in neurons of the reeler ectopic cortical plate.

These studies have also pointed to a possible role of Rac1 and Rac3 proteins in the later development of specific populations of MGE-derived interneurons (Vaghi et al. 2014), and provided evidence for cytoskeletal defects observed in cultured MGE-derived neurons from Rac1/Rac3 double mutant mice that may underlie the observed migratory defects (Tivodar et al. 2015).

Several of the ocular defects are similar to defects observed in Col18a1−/− mice [8].

stage before any morphological defect observed.

Notably, we observed cell migratory defects in the developing endothelial compartment.

Besides myospheroid, we have also shown that rhea (talin homologue) and fermitin 1 (kindlin 1 homologue) depleted hemocytes suffer from similar migratory defects, both showing significant decreases in the mean cell speed, a phenotype that has been previously observed in HT-1080 talin-depleted cells in a 3D in vitro assay (Fraley et al., 2010).

Importantly, Rac1,2−/− DCs have severe migratory defects and cannot extend polarized dendrites towards T cells [13], thereby fail to promote T cell activation, similarly to what we observed in PLCγ2−/− DCs.

Taken together, Mesp2 can induce mesoderm and EMT in ESCs, and compensate for differentiation and migratory defects in Mesp1-deficient embryos.

Rac1,2−/− DCs have migratory defects in vivo and fail to induce T cell priming due to impaired interactions with T cells [13].

Compensation by other FLN isoforms is a likely explanation for the lack of major migratory defects in most tissues of single knockout animals.

Moreover, an evident accumulation of CB-positive precursors along the migratory pathway as a consequence of migratory defects has not been detected by us.