The migratory ability was not affected.
Importantly, this modulation in signal transduction directly affected the migratory ability of endothelial cells.
The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue repair.
Doxorubicin-induced cytoskeleton remodelling suggests that doxorubicin may alter the migratory ability of EPCs.
However, incubation of cells with NSC23766 suppressed the enhanced migratory ability of SSc fibroblasts to that of controls (Figure 4).
Migratory ability of BCPAP, 8505C, CGTHW-1 and ML-1 cells was also assessed by a scratch wound assay.
Our previous research also indicated that PRL-3 with inactive PTP domain reduced the migratory ability of tumor cells [3].
These results suggest that Sema3E confers a migratory ability to OEC cells through Plexin-D1 in an autocrine manner.
The migratory ability of tumor cells was assayed in Transwells (Costar, Cambridge, MA) as reported previously [39].
However, it should be noted that alteration of glycosyltransferase activity in cell line models have shown differential effects on migratory ability in vitro [38], [39], [40].
Briefly, 96-well Boyden's chamber was used to measure cell migratory ability and a polycarbonate membrane with 8-µm pores was used in these experiments.
