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This correlates well with the overall migratory abilities of different Seam3E-expressing OEC cells in the wound-healing assay.
The adhesive and migratory abilities of tumor cells and the tumor microenvironment are key components involved in cancer metastasis [2], [3].
It would be interesting to assess whether direct contact between segregated central with peripheral RPE cells could alter the proliferation or migratory abilities of the latter.
Although many cellular and molecular components are involved in cell migration, this striking observation led us to query whether selective reduction of the CCT-eta subunit alone might alter the migratory abilities of adult fibroblasts, in effect rendering them more "fetal-like" in behavior.
Rosiglitazone posed an inhibitory effect on both invasive and migratory abilities of H441GL cells (see Additional file 4).
It was observed that both invasive and migratory abilities of MKP-1 over-expressing H441GL cells were severely affected.
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The regenerative abilities of sponges, their lack of a central coordinating organ (brain), and the peculiar migratory ability of cells within the organisms combine to make it somewhat difficult to define sponge individuality.
Importantly, this modulation in signal transduction directly affected the migratory ability of endothelial cells.
But why would migratory ability of cancer cells be advantageous in the first place, given that non-migratory cells in the primary tumor might have the advantage that resources could be spent on cell division rather than migration (Bernards and Weinberg 2002)?
Although no significant differences in the levels of membrane transporters such as P-glycoprotein or multidrug resistance protein 1 (MRP1) were detected, the cell migratory ability of the ET-743-resistant cell variant was reduced, as was its attachment capability to gelatin-coated cell culture dishes.
Doxorubicin-induced cytoskeleton remodelling suggests that doxorubicin may alter the migratory ability of EPCs.
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