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The mediation of mitogenic effects of KGF by ERK1/2 signaling has also been reported in other cell types such as endometrial cells [42], [43] while other effects of KGF such as regulation of cell migration were mediated by MAP Kinase P38 [43].
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Owing to the integral role of pS6K in cancer cell migration, it is possible that honokiol-mediated inhibition of migration is mediated through pS6K inhibition.
The way cells explore their surrounding ECM during development and migration is mediated by protrusion of actin-rich structures at the cell front.
These findings support both our hypotheses, first that insect hemocytes can detect and respond to fMLP, and second, that insect hemocyte migration is mediated by eicosanoids.
The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward.
In conclusion, we show here that Netrin-1-enhanced SCs migration is mediated by activating p38 MAPK and PI3K-Akt signal cascades via receptor UNC5B, which suggests that Netrin-1 could serve as a new therapeutic strategy and has potential application value for PNS regeneration.
This migration is mediated by the chemokine CXCL12, which is upregulated by seizures.
Together, these results strongly suggested that the enhancement of OECs migration was mediated by reactive astrocyte-derived TNF-α.
Therefore, it may be reasonable to think that LPA-induced activation of ERK and enhanced cell migration is mediated through PAK1.
We also demonstrate that LTD4 mainly internalizes the CysLT1R, supporting our previous findings that LTD4-induced cell survival, cell proliferation, and cell migration are mediated through the CysLT1R.
Thus, S100A4 blockade by specific antibodies appeared to considerably decelerate RANTES-induced migration of S100A4-positive fibroblasts, directly confirming that RANTES-driven cell migration is mediated at least partially by S100A4.
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