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In total, this data suggests that dcEFs guide osteoblast migration via a Ca2+-dependent mechanism.

In particular, locostatin reorganizes the actin cytoskeleton, disrupts the mitotic spindle and inhibits cell migration via a mechanism that is independent of the MAPK pathway.

Our data fit well with findings of Chen et al., (2002) who described that activation of the β2-adrenergic receptor inhibits keratinocyte migration via a cAMP-independent mechanism [39].

ERK, a member of the mitogen-activated protein kinase (MAPK) family, is reported to be associated with lamellipodial dynamics [23] and chemotactic migration via a ROS-dependent way [24], [25], [26].

We, thus, propose that Gβγ-signaling inhibits the Epac-induced cell migration via a Ca 2+-dependent mechanism in melanoma.

We thus propose that Gβγ-signaling inhibits the Epac-induced cell migration via a Ca 2+-dependant mechanism in melanoma.

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Similar(44)

These results suggest that locostatin regulates cell migration via an RKIP-dependent, Raf/MAPK-regulated mechanism.

Since interstitial flow can also induce tumor cell migration via an autologous chemotaxis mechanism [42], it would remain interesting to know whether HSPGs play any roles in this mechanism.

Hypercapnic acidosis appears to inhibit pulmonary epithelial wound healing by reducing cell migration via an NF-κB-dependent mechanism.

As it has been shown that glutamate can promote OPC migration via an αv integrin/myelin proteolipid protein complex (Gudz et al., 2006), it is conceivable that these synapses could regulate OPC migration in an activity-dependent manner.

A recent study demonstrated that the tryptophan catabolism enzyme TDO is overexpressed in human brain tumors, and elevated secretion of kynurenine promotes cell migration via an AhR-dependent pathway [ 25].

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