Although the specific biological functions of ADAMs are not well elucidated at the present time, they may be involved in cell-cell interaction, cell migration, signal transduction, shedding of various membrane-anchored proteins and degradation of ECM components under pathophysiological conditions such as fertilization [ 4, 5], morphogenesis [ 6, 7], angiogenesis [ 8] and cancer [ 9].
Under pathophysiological conditions like hypoxic microenvironments, the subsequent metabolic switch to an increased rate of fermentative glycolysis is a common affair to cancer cells3,33.
Under pathophysiological conditions such as acute ischemia, however, Cx43-deficient mice exhibit increased incidence and earlier onset of ventricular arrhythmias.
It is now proposed that ATP concentrations sufficiently high to activate P2X7R are present only in damaged cells/tissues under pathophysiological conditions or when a high-intensity mechanical load is placed on the skeleton.
The expression of housekeeping genes generally serves as a reference for mRNA amount, assuming that it remains stable under pathophysiological and experimental conditions.
NIRS has demonstrated utility for monitoring changes in muscle oxygenation and blood flow during submaximal and maximal exercise and under pathophysiological conditions including cardiovascular disease and sepsis.
This review focuses on a relatively new methodology for investigating renal epithelial transport, computational modelling and highlights recent insights regarding renal Na and K transport and O2 consumption under pathophysiological conditions, with a focus on nephrectomy.
This movement of fluid is increased to several times a day under pathophysiological conditions associated with systemic inflammation (trauma, sepsis) owing to increased capillary permeability [34],[34].
Under pathophysiological conditions, BoNTs prevent neurotransmission from almost every type of neuron suggesting common targets present in the majority of neurons.
The traditional view has been that ROS exert toxic effects by damaging or killing cells under pathophysiological conditions.
