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We anticipate that such biomimetic hydrogel walkers could form the basis of light-actuated soft robots capable of more advanced functions, such as autonomous migration to specific locations accompanied by triggered release of molecular cargo.
Since these chemical gradients direct cell differentiation into specific tissue types and guide cell migration to specific locations [11], [12], controlling these gradients will be a key requirement when engineering complex tissues for organ regeneration.
It has been shown that leukocytes express multiple different chemoattractant receptors in a cell subset dependent manner, and can integrate multiple co-existing chemotactic signals to direct their migration to specific targets in tissues that enable immune surveillance and immune responses [9], [11].
Chemokines and chemokine receptors are important regulators of DC migration to specific anatomic areas such as lymph nodes and sites of infection, and thus have an important effect on DC function.
Moreover, recent data indicate that HS and syndecan protect the host from various inflammatory disorders by neutralizing chemokines, attenuating exaggerated T-lymphocyte homing, and confining neutrophil migration to specific sites of tissue injury.
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Yet, it is not possible to use GDP variation to estimate the effect of migration to one specific country since this instrument only represents an overall pull effect.
Like V. fischeri, Verminephrobacter colonize their hosts by recruitment from a mixed microbial community, migration to a specific host tissue, and attachment (Davidson and Stahl 2008).
Lymphocyte migration (homing) to specific tissues has an important role during protective and pathological immune responses, including inflammatory bowel diseases.
In particular, it is important to ensure that our analysis of migration responses to specific shocks are not mixed with demographic changes also affecting the patterns of regional population.
The increased expression of CXCR4 on these cells allows a potent response to CXCL12 and migration to site-specific regions of the body [ 135, 136].
They are well equipped to locate prey and their own kind; to direct the course of their seasonal migrations; to discriminate specific localities; to respond to variations of temperature; to react to attractive or repelling substances in the water; and perhaps even to feel objects some distance away from them.
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