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Exact(31)
CCR7 directs migration to lymph nodes, with naive T cells migrating through high endothelial venules, and maturing tissue dendritic cells to afferent lymphatics.
Their success partially depends on accurate delivery of cells to target organs or migration to lymph nodes.
As noted above, the hydrodynamic particle size of the AuNV can be important for particle migration to lymph nodes.
In conclusion, we successfully monitored the proliferation of DCs and their migration to lymph nodes in live mice by performing 18F-TFB PET imaging of the NIS gene and optical imaging of the effluc gene.
In addition to these effects, the milieu of hormones produced at this time (leptin, pituitary growth hormone, and prolactin) support the interactions between APCs and T-cells, a shift of the Th1/Th2 cytokine balance towards one that supports Th1, an increase in overall Th cell proliferation, and naïve T cell migration to lymph nodes.
Thus, active virus replication appears to lead to higher CCR7 expression and pDC migration to lymph nodes, but not to higher IFNα expression by lymph node-homed pDC.
Similar(29)
In addition, actin cytoskeleton rearrangement is important for the motility and migration of cells and may influence the migration of DC to lymph nodes during their maturation [ 45].
Next, we sought to determine whether there might be underlying mechanisms that compensate the migration of pDC to lymph nodes in HIV-1 patients, thereby offsetting in part accumulation of these cells.
The migration of T cells in a murine model of diabetes [13] or the migration of dendritic cells to lymph nodes [14] was visualized by this modality.
TNF-α is known to stimulate the migration of Langerhans cells to lymph nodes and to enhance the capability of presenting antigen to primed T cells.
This observation is in agreement with the already published data concerning the CCL19- and CCL21-dependent migration of mature pDCs to lymph nodes [ 17].
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