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Finally, TNFSF4 expressed on endothelial cells was reported to mediate the adhesion of TNFRSF4-expressing T-cells to vascular endothelial cells and the subsequent migration to distant inflammatory sites [35], suggesting an involvement of TNFSF4 in lymphocyte recruitment as well.
Uncontrolled growth, survival and migration to distant sites are hallmarks of aggressive tumors.
Secreted miR-105 targets tight junction protein ZO-1 in endothelial cells, thereby facilitating cancer cell migration to distant locations.
It is hypothesized that tumor cells acquire metastatic potential following an epithelial to mesenchymal transition (EMT) that permits local invasion and migration to distant metastatic sites.
The P2Et fraction exerts its activity on the primary tumor, reduces cell migration to distant organs, and decreases IL-6 serum levels, implying tumor microenvironment mechanisms.
Tumour suppression was equally affected by DC inoculation adjacent to the tumours and intravenously, emphasising effective DC migration to distant sites.
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Mesenchymal-like cancer cells could more effectively invade surrounding tissues and migrate to distant sites in ways that can reflect cell migration during development.
Cancer metastasis consists of several interdependent processes including uncontrolled cell proliferation, invasion through surrounding tissues, migration to the distant sites of the human body, and adhesion, invasion and colonisation of other organs and tissues (Price et al, 1997).
Since anoikis resistance may correlate with the ability of cells to survive detachment from the primary tumour mass and proliferate after migration to a distant site, targeting NRP-1 may increase anoikis in tumour cells and thereby decrease formation of metastases.
The reconstruction of the geographic range history indicates that migrations to geographically distant mountain ranges represented rare events - the Western Black sea area, the Western Alps and the Western Romanian Carpathians were probably colonized only once.
An early injection in the liquid phase may result in bone cement extravasation into the venous system as well as its distant migration to the lungs [ 10, 21].
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