Suggestions(2)
Exact(1)
These findings suggest that cell migration stimulated with Wnt may be independent of canonical signalling.
Similar(59)
Interestingly, migration stimulated by VEGF121 together with bFGF and IGF-1 was totally blocked by ranibizumab, although bFGF-induced migration was not affected, and VEGF121 by itself did not even enhance iBREC migration.
Moreover, migration results also showed that the L1 antibody-induced increases in migration of neurons stimulated with L1 antibody were significantly decreased by 35% after transfection with FUT shRNA and 60% after transfection with ST6Gal1 shRNA when compared to mock-transfected neurons (Fig. 4D).
I3MO also blunted migration of VSMC stimulated with the PDGF, the strongest motogen tested in this study.
The Rac1 peptide is able to block endogenous Rac1 signaling within minutes by competing with Rac1 effector proteins and, in vitro, has been demonstrated to possess a potent capacity to block actin polymerization and migration of human cells stimulated with SDF-1α [ 11, 29, 30].
AG1478 inhibited migration of GFP control cells stimulated with EGF as well as EGF-independent migration of Vav1Y3F cells (Fig. 4B).
However, the addition of DS-SILY20 caused a dose-dependent inhibition of PDGF-stimulated SMC migration in proliferative SMCs, where PDGF-stimulated cultures treated with 10 μM DS-SILY20 exhibited a 94% decrease in migration compared to proliferative SMCs stimulated with PDGF alone.
Indeed, cysteinyl leukotriene alone could induce cell migration only when A431 cells were stimulated with EGF in the presence of 5-LO Xinhibitors (Fig. S6).
By comparing the migration and cell growth of BMSCs stimulated with conditioned media from co-cultures of WT cells and IL-6 KO cells, it was found that only conditioned media containing IL-6 stimulated the migration and increased the cell numbers of BMSCs, while conditioned media lacking IL-6 could not.
These results can be explained by other findings that CysLT2 has inhibitory effects against tumor progression and the migration of cancer cells; 36, 37 therefore, LTC4 may bind to CysLT2, and the downstream signaling of CysLT2 could suppress cell migration when A431 cells are not stimulated with EGF.
Reducing the levels of PKCε, but not of PKCα or PKCδ, with siRNA inhibited migration both under basal conditions and when cells were stimulated with TPA.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com