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However, this apparent effect could be explained by the lower migration speed in TACC3-depleted cells because the directionality ratio between distance migrated and displacement (d/D) was not significantly different from the control group (Fig. 5D).
The broken lines in (a) denote the migration speed in km/day.
c i is the particle's migration speed in the i direction.
The average migration speed in µm/hr was calculated and graphs were plotted using Microsoft Excel and Sigma plot program.
Overall, the results suggested that the cell migration speed in Table 2 might be close to optimal.
Microfluidic devices used to measure neutrophil directional migration speed in response to chemoattractant gradients were manufactured using standard techniques.
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We varied cell and cluster migration speeds in a series of simulation experiments.
This is likely the main reason why downstream migration speeds in these other rivers were slower on average than coastal speeds, even though coastal travel would have little assistance from currents.
Interestingly, T cells maintain similar migration speeds in the 5 nM CCL19 gradient when compared with those observed in a 100 nM CCL21 gradient or 100 nM uniform CCL21 field (Figure 2), suggesting the motile nature of activated T cells.
(E ) Boxplot comparing the migration speeds in control vs MZ amotl2a −/− mutant pLLP.
However, although overexpression of Mena reduces fibroblast migration speeds in vitro, the authors show here that Ena overexpression increases macrophage migration speeds in the embryo, consistent with previous findings that Mena overexpression increases cell motility and metastasis in breast cancer.
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