Mice lacking the α1, 3 fucosyltransferases were generated several years ago and demonstrate loss of selectin binding activity, impaired T cell migration to draining lymph nodes but normal migration to spleen, as well as impaired T cell extravasation to skin in both contact hypersensitivity and viral models [12], [19].
This is suggests that E2 may promote the migration of PDCs into spleen tissue so as to lead to the elevated IFN-α/β expression in the local region, and then the production of IgM was increased in the plasma.
C-X-C chemokine ligand (CXCL 10- and CCL5-induced migration of cultured and spleen-retrieved effector T cells was unchanged (Fig. 4E).
This event signifies the migration of cytokines into the spleen, within which the differentiation of Th0 cells takes place.
This was associated with a significant decrease in CD62L expression, a cell surface molecule implicated in lymphocytes homing to peripheral tissue, suggesting the migration of lymphocytes from the spleen to the periphery.
To test the implicit assumption that migration of radioactivity from liver, spleen and bone marrow to kidney and bladder is an indicator of gradual efflux of radioactivity from living or dead labelled cells, we examined the distribution of activity after injection of [Zr]oxinate4 and that of cells that had been killed/lysed after radiolabelling with Zr and In.
Both genotypes had a loss of B cells after infection, and we believe this represents the migration of B cells to the spleen, the known major reservoir for latent viral infection [ 42].
Migration of Fasciola hepatica to the spleen and pancreas and perhaps the kidneys was considered as the cause of the imaging findings in this patient, however hypersensitivity reaction to Fasciola antigens might also be implicated.
Collectively, these data suggest that there is only a very narrow window of time following infection when malaria-specific ASCs are found in peripheral blood, and, taken with the kinetics of plasma cells in spleen and bone marrow, reflect the migration of malaria-specific plasma cells from the spleen to the bone marrow.
