Sentence examples for migration of primordial from inspiring English sources

We report a genetic and functional analysis of Tre1, a GPCR that is essential for the migration of primordial germ cells in Drosophila melanogaster.

Boldajipour et al. [19] proposed that by removing CXCL12 at the posterior side CXCR7 sharpens the chemotactic gradient promoting CXCR4-dependent migration of primordial germ cells.

In Drosophila melanogaster germ cells, the GPCR Trapped in endoderm 1 (Tre1) appears to be a functional analog to CXCR4 in vertebrates, playing a critical role in the migration of primordial germ cells [18] [21].

Furthermore, Pum is also involved in the development and migration of primordial germ cells [20], [21], [22], and it may be implicated in long-term memory formation and neuronal excitability [23], [24], [25].

The present observation provides an explanation for the efficiency of CXCR7 in supporting CXCR4-mediated migration of primordial germ cells and is consistent with the view that CXCR7 that is expressed by somatic cells functions as a scavenger.

While Valentin et al. [17] propose active signaling through CXCR7 for the migration of the lateral-line primordium, Boldajipour and colleagues suggested that CXCR7b expressed in somatic cells facilitates the CXCL12/CXCR4-mediated migration of primordial germ cells by controlling the level of the chemokine in the environment, thereby contributing to the formation of a chemotactic gradient [19].

They occur mainly in the gonad, but also in specific extragonadal sites along the migration route of primordial germ cells.

The remainder arise in various midline or near-midline sites, presumed to be due to arrested or aberrant migration of the primordial germ cells during foetal development.

The life cycle of mammals is characterized by two phases of major epigenetic reprogramming: first during migration of the primordial germ cells (PGCs) to the genital ridge in the developing embryo, and the second after fertilization during pre-implantation development [ 1].

Previously, by using zebrafish, Doitsidou et al. [ 15] and Knaut et al. [ 16] have demonstrated that the CXC chemokine cxcl12a (sdf-1a) and its receptor cxcr4 are critical for proper migration of the primordial germ cells, the progenitors of the gametes.

Development of germ cells in female rodents initiates with the migration and colonization of primordial germ cells (PGCs) from the yolk sac to the urogenital ridges [1].