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The SKOV-3 cell line migrated more rapidly through TN than through BSA indicating that TN can facilitate migration of ovarian carcinoma cells.
ARHI, a putative tumor suppressor protein with unique 32 amino acid extension in the N-terminal region, differs from oncogenes Ras and Rap, negatively regulates STAT3 signaling and inhibits the migration of ovarian cancer cells.
A study using fluorescence technique to show the preferential migration of ovarian cancer cells to the mouse omentum revealed that cancer cell migratory behavior can be mediated by adipokines secreted by omentum-associated adipocytes, including chemokine C-C motif ligand 2 (CCL2), IL-6, IL-8, tissue inhibitor of metalloproteinase 1 (TIMP1), and adiponectin (Nieman et al., 2011).
We therefore determined if EphB4 participates in the migration of ovarian cell lines.
Thus, loss of CCBE1 expression enhances migration of ovarian cancer cells in vitro.
It is predominantly secreted by fibroblasts and plays a role in adhesion and migration of ovarian cancer cells [ 19].
Similar(40)
Similar approaches using this methodology have been useful in determining the migration speed of ovarian carcinoma cells, showing that the α-2 integrin subunit is essential for migration (Kokenyesi et al, 2003).
The migration capability of ovarian cancer cells was measured after being treated with TSA, 5-aza-CdR, and cisplatin alone or in combination, and cell migration of all three cancer cell lines was significantly inhibited by TSA, 5-aza-CdR, or cisplatin alone as well as when cisplatin was combined with TSA or 5-aza-CdR.
Migration of an ovarian carcinoma cell.
Previous studies demonstrated that ML 141 inhibits the migration of human ovarian carcinoma cell lines OVCA429 and SKOV3 without exhibiting cytotoxicity [ 26].
Particularly, the enhanced migration of human ovarian carcinoma cells has been shown to involve Rab-coupling protein-dependent recycling of α5β1-integrin and coordination of its tracking with that of EGFR [ 83].
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