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Nonetheless, in the case of "nuclear migration" (thought to be a common process of neuroepithelia in development and enabling the migration of nucleus between apical and basal surfaces) both of the molecules in this cluster were overexpressed in HGMEC and also in the regulatory microtubule associated molecule Tpx2 [ 19].
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It is critical to note that the oscillations took place after fountain streaming and were therefore not due to the natural migration of nuclei from the anterior to the posterior of the embryo.
Rather, the motion is presumably due to the more rapid nuclear divisions in the warmer half of the embryo causing an overcrowding of nuclei and an accompanying migration of nuclei from the warm posterior of the embryo to the cool anterior of the embryo.
Nuclear motion is correlated with cell cycle, and the oscillatory behavior is presumably due to an accompanying opposite migration of nuclei towards the posterior of the embryo after nuclei in the cool anterior half undergo a division (Figure S3, Movie S3).
Besides their primary function in connecting nucleoplasmic to cytoplasmic structures, LINC complexes are supposed to be directly involved in dynamic processes concerning anchorage and migration of nuclei (reviewed in [3]) but also positioning and movement of nuclear structures (i.e. meiotic telomeres) [23] [24].
Activation of satellite cells ultimately leads to migration of nuclei to the damaged area of the muscle fiber.
The germline forms in embryos by the migration of nuclei into a region of specialized cytoplasm containing germline determinants.
The 8 th cycle coincides with the migration of nuclei to the periphery of the embryo (forming the syncytial blastoderm).
If this is the case, apical-to-basal migration should be affected by the acute perturbation of basal-to-apical migration of nuclei in G2-phase.
In Drosophila, LB2 regulates the apical migration of nuclei in differentiating photoreceptors (R cells) by connecting the microtubule-organizing center (MTOC) to the nucleus to regulate nuclear translocation, a critical process for neuronal nuclear migration (Patterson et al., 2004).
Failure during syncytial development commonly involves mass migration of nuclei throughout the embryo, making it difficult to distinguish the point of failure between pre-gastrulation death resulting in nuclei migration and premature gastrulation that causes death.
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