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Thus, HCMV impedes MHC class II molecule trafficking, dendritic projections, and migration of mature LC.
C-C chemokine receptor type 7 (CCR7) and its ligands direct the migration of mature DCs and establish a functional microenvironment to prime naive T cells.
Consistent with this result, elevated CXCL12 as discovered in this study points to pathogenesis in the recruitment of B lymphocytes, as previous reports suggest CXCL12 to be a critical chemoattractant in trafficking and migration of mature autoreactive B cells [45].
Such symptoms require directed migration of mature mast cells or their precursors.
CD38 has been reported to be required for the migration of mature DC against recombinant CCL19 [29].
In this study, we analyzed the role of Jak3 in the migration of mature DCs both in vitro and in vivo.
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These results demonstrate the importance of plexinD1 in directing migration of maturing thymocytes via modulation of biological responses to chemokine gradients.
Given the fact that SFA efficiently inhibited chemokine production by human moDCs we next questioned whether SFA also directly inhibits moDC migration of maturing DCs (Figure 7 A).
HMGB1 is further required for the migration of maturing DCs.
This would facilitate the migration of maturing DCs from peripheral tissues to lymph nodes.
To further study the role of Jak3 in CCR7-dependent DC migration, we analyzed the migration capacity of mature BMDCs (mBMDCs) derived from Jak3−/− and Jak3+/+ mice using in vitro chemotaxis assays.
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