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Furthermore, migration of grafted cells from the graft edge was enhanced in the grafts both rostral and caudal to the lesion site in L1 overexpressing SENAs versus wild-type SENAs (Fig. 3D, E).
Morphological analysis of transplanted cells revealed that overexpression of L1 beneficially influences survival and migration of grafted SENAs, neuronal differentiation of and neurite outgrowth from grafted SENAs.
These interactions with the cytoskeleton are likely the basis for the enhanced migration of grafted cells into the host tissue, another beneficial property of L1 that has previously been described [13], [16].
Despite promising work in mouse models of DMD [6], clinical trials of myoblasts in DMD patients were disappointing [7] [9], the main problems being low survival and migration of grafted cells and the low number of donor-derived muscle fibres [10].
Histopathological examinations with prussian blue staining for iron, immunohistochemistry, and confocal analyses demonstrated the survival and migration of grafted SPIO-labeled hNSCs towards the ischemic region.
Engraftment and migration of grafted cells through nonembryonic bowel have been quite limited (139, 196), and it is unclear what functional capabilities these cells could have once engrafted, although they do extend neuronal processes.
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Surgical repair by EVAR has a number of potential complications including migration of the graft and endoleaks (pooling of blood outside the graft within the excluded aneurysmal sac).
Migration of Schwann cells grafted in the CNS is largely compromised by their exclusion from astrocytes (Lakatos et al., 2003).
Understand the purpose of grafting.
This is interpreted as saturation of the interface by block copolymer due to the mutual migration of the PA and grafted PP polymer chains that becomes possible when the PA melts.
Friction, column strength and tissue ingrowth do not prevent migration of the stent graft from its attachment within the neck into the aneurysm; some form of active fixation is required, usually in the form of barbs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com