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The migration of endothelial cells (ECs) plays an important role in vascular remodeling and regeneration.
Hou, Y. et al. Endothelial-monocyte-activating polypeptide II induces migration of endothelial progenitor cells via the chemokine receptor CXCR3.
Burgett, M.E. et al. Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells.
Kim, B., Li, J., Jang, C. & Arany, Z. Glutamine fuels proliferation but not migration of endothelial cells.
Coordinated migration of endothelial cells models the remodeling of existing endothelia as well as angiogenesis and vasculogenesis.
Haptotatic migration assays demonstrated the ability of LysB10.V2 surfaces to stimulate migration of endothelial cells (P < 0.05).
Vascular endothelial growth factor (VEGF) is known to promote the proliferation and migration of endothelial cells during angio- and arteriogenesis.
Angiogenesis occurs through a multi-step process that includes the release of pro-angiogenic factors, the release of proteolytic enzymes, the migration of endothelial cells (ECs) toward tumors, the proliferation of ECs, and the formation of functional capillary lumens.
After demonstrating their binding ability to vascular endothelial growth factor (VEGF), we show that they suppress VEGF-induced migration of endothelial cells.
FGF-2 and PMA (a protein kinase C activator) both stimulated migration of endothelial cells at 2.2- and 3.1-fold, respectively.
Bioactivity of the loaded growth factors towards proliferation and migration of endothelial cells (HUVECs) was evaluated through MTS and Boyden chamber assays respectively.
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