Chen, G. et al. Semaphorin-3A guides radial migration of cortical neurons during development.
López-Bendito, G. et al. Blockade of GABA(B) receptors alters the tangential migration of cortical neurons.
The HA-rich zones, those sandwiched the cortical plate, might avoid further migration of cortical cells.
Zarbalis, K., Choe, Y., Siegenthaler, J. A., Orosco, L. A. & Pleasure, S. J. Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice.
The functions of CR cells modulating migration of cortical plate neurons seemed to remain unaltered in the absence of Sema3E/PlexinD1 signalling (see Fig. 6).
Our findings indicate that migration of cortical neurons is enhanced on soft substrates, leading to a faster formation of neuronal networks.
During corticogenesis, CR cells seem to play several roles: modulating appropriate migration of cortical plate neurons, actively participating in neuronal network activity in developing marginal zone/layer I, with the capacity to generate action potentials, establishing synaptic contacts in the marginal zone/layer I and receiving excitatory and GABAergic inputs9,10,11.
Together, these results suggest that the sst2A receptor could play a role in the early events of the radial migration of cortical excitatory neurons.
Reelin is another key protein active during cortical development as the lack of reelin results in aberrant migration of cortical neurons and misaligned radial glial cells [29], [30], [31], [32].
These results demonstrate that Dpy19l1 regulates radial migration of cortical glutamatergic neurons during development.
Our work unveils a function for GlyR activation in the tangential migration of cortical interneurons.
