The model predicted neither stable nor transient symmetric expansion of the contact, but rather lateral migration of the contact to the recycling point, near which it subsequently stabilized.
In this model system, the contact is immobilized, and therefore the predicted migration of the contact over the surface of the TC was expected to be manifested by a congruous movement of the TC on the immobile substrate in such a way that the eccentric intracellular RC-MTOC-GA complex would become positioned over the cell-substrate contact.
The migration of the contact area around the TC occurred via advancement of the contact boundary that was already closer to the recycling point, while the synapse boundary that was father away from it retracted.
Therefore, even though the manner of the relative movement of the contact and the GA that is seen in our time-resolved three-dimensional data is consistent with the migration of the contact to the GA, these data does not argue either way whether it is the contact that is actively moving to the GA or the GA to the contact.
In the general case wherein the TC-APC contact is initiated in an arbitrary orientation to the RC, the modeling predicts that the contact dynamics and receptor recycling can interact, resulting effectively in migration of the contact to the TC surface domain adjacent to the submembrane RC.
The new theoretical prediction of the migration of the contact to the organelle complex, however, stipulated two more specific features of how this relative position should be achieved.
The lateral migration of the contact zone is therefore also not exclusively due to the adhesion being stronger where the TCR density is higher.
The predicted migration of the contact area toward the intracellular RC-MTOC-GA complex stipulated that the relative movement of the two structures should be a mutual approach along the cell circumference.
In comparison to the pull mechanism, the migration of the contact area around the TC to the region proximal to the RC in our model stipulates, first of all, that the intracellular RC is initially eccentric.
As a result of the importance of dietary aluminum exposure (see "Aluminum in or resulting from food additives" above) and the common use of aluminum food contact materials (see "Aluminum from food contact materials" above), in particular in private households, the migration of aluminum from contact materials to food was examined.
