Sentence examples for migration of confined from inspiring English sources

Indeed, A375 cells adhered to fibronectin-coated coverslips (either 5 or 50 µg/ml) did not migrate, while leader bleb-based migration of confined non-adherent cells was very fast at 1.15 ± 1.02 µm/min (mean ± SE, Figure 1N).

Thus, Eps8 promotes formation of a large leader bleb to drive migration of confined, non-adherent A375 cells.

The work described here elucidates the importance of a specific Erk effector, Eps8, in the migration of confined melanoma cells.

Thus, Eps8 is required for leader bleb formation to drive migration of confined, non-adherent cells in several cancer cell types, independent of the defect driving transformation.

Our study shows for the first time a critical role for Eps8 and its regulation of the actin cytoskeleton in promoting cell cortex tension and intracellular pressure to induce the rapid, adhesion-independent migration of confined cancer cells.

Together, these results suggest that Erk-mediated phosphorylation of S624 and T628 coordinates the local co-regulation of Eps8 capping and bundling activities to control cortical tension and intracellular pressure to mediate leader bleb formation and migration of confined cells.

It is becoming apparent that unraveling the mechanisms of confined cell migration in this context requires a multi-disciplinary approach through integration of in vivo and in vitro studies, along with sophisticated bioengineering techniques and mathematical modeling.

Ratio of the volume of transverse confining steel to the volume of confined concrete core.

Due to its precise channel architecture, it allows for a quantitative analysis of mechanical deformation of cell migration through confined environments.

Hence, upward migration of the underlying confined groundwater of the Upper Muschelkalk was excluded just as in the city of Staufen.

Here, we highlight such an approach that has led to discovery of a new model for cell migration in confined microenvironments (i.e., the Osmotic Engine Model).