Sentence examples for migration of cerebellar from inspiring English sources
In addition to the present results, it has been reported that in the CNS, in addition to CR cells, the migration of cerebellar granule precursors34, cortical interneurons23, microglia45, neural precursor cells46, and certain brain tumour cells33 is also dependent on CXCL12/CXCR4 signalling.
The radial fibers of Bergmann glia also act as essential guide rails for the migration of cerebellar granule cells [4], [5].
For example, CME drives the polarized trafficking of growth factor BDNF in the directed migration of cerebellar granule cells [78], and axon growth cone dynamics rely on both endo- and exocytosis in regulating turning responses to guidance cues [30], [31].
Moreover, to investigate whether L1-mediated neuronal survival and migration can be mimicked by L1 antibody treatment, we first determined the effect of L1 antibody 557 on migration of cerebellar neurons and neuronal survival.
Subsequent migration of cerebellar neurons is disrupted, associated with disordered radial glial morphology.
However, we have recently reported that BMI1 also regulates cell adhesion and migration of cerebellar progenitors through repression of the BMP pathway [ 17].
A migration impairment of cerebellar granule neurons occurs when Rac1 is ablated (Tahirovic et al. 2010).
In a neurophysiological context, neurotypical development of the cerebellum requires cell communication by the Shh morphogen to trigger proliferation, differentiation and migration of the cerebellar granule cell progenitors61,64,65.
Recently melatonin MT2 receptors were shown to stimulate the migration of rat cerebellar granule cells mediated by delayed rectifier outward potassium current (Liu et al. 2007a).
It has been previously shown that binding of J-Ab to the ganglioside 9acGD3 impairs the migration of rat cerebellar GCPs in vitro and in vivo (Santiago et al., 2001, 2004).
We previously reported that brain-selective deletion of DG in mice recapitulates some of the brain malformations characteristic of severe dystroglycanopathy, including aberrant migration of cortical and cerebellar neurons, and further showed severely blunted hippocampal long-term potentiation in these mice [ 5].
