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The present study indicates that collagen fragments can mediate the migration of bone marrow stromal cells.
Chemokines are known to induce the directed migration of bone marrow CD34− mesenchymal stem cells (MSCs).
Human marrow stromal cell and trabecular osteoblasts rapidly proliferate on the scaffold up to 3 weeks, promoting an oriented migration of bone cells along the fibre arrangement.
Overall, all the conditions studied promoted the growth and migration of bone marrow mesenchymal stem cells in the fabricated poly(ɛ-caprolactone) scaffolds, without affecting their chondrogenic differentiation and extracellular matrix deposition evaluated by Alcian Blue staining.
Previous studies have shown that Cxcl12 is a catabolic factor that can infiltrate cartilage, reduce proteoglycan content, and increase MMP-13 activity.45 Inhibiting the Cxcl12/CXCR4 signaling pathway can attenuate the pathogenesis of OA.46 Moreover, it also induces the migration of bone marrow MSCs to articular lesion sites.
With in vitro studies, it was observed that CXCR4 gene expression and migration of bone mesenchymal stromal cells and hypo-dermal fibroblasts were more sensitive to exogenous SDF-1 alpha, while expression of tendon repair gene markers by hypo-dermal fibroblasts and Achilles tendon fibroblasts were more sensitive to exogenous SDF-1 alpha.
Similar(26)
They have been used to track the delivery of microspheres and migration of bone-marrow-derived cells to tumors (Stroh et al., 2005).
Interestingly, as we observed a mobilisation of HSCs from bone marrow to peripheral blood in treated animals, we suggested that ProAbe could favour the migration of bone-marrow-derived progenitors and their participation in muscular regeneration and endothelial formation.
The hydrogels were characterized with respect to sol fraction, water uptake, degradation, SDF-1α loading efficiency and release kinetics, and migration rate of bone marrow stromal (BMS) cells.
Yu, J. et al. SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/Akt.
Gong, J. et al. The SDF-1/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis.
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