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The ability to switch between protrusion types and motility modes has been proposed to facilitate cancer dissemination; switching could indeed allow cells that migrate through complex and changing environments to select the most efficient migration mode for a given environment (reviewed in [ 8,46,48]).
Additionally, mechanical forces exerted by tumor cluster on extracellular microenvironment are likely to play a pivotal role in this migration mode switch induced by TGF-β and need further investigation.
More explicitly, electrophoresis of RBCs superimposed on the pressure-driven flow is utilized to generate an RBC migration mode analogous to this phenomenon.
The inhibitory effect on invasion was maintained independently by the migration mode utilized by the cells in our 3-D model, and was accompanied by an impaired formation of actin-based cytoskeletal protrusive structures.
"We have shown that migrating cells prioritize certain cues in the presence of others and thus can switch their migration mode, depending on what they see from the environment," said first author Benjamin Lin, a postdoctoral associate in biomedical engineering at Yale.
However, rising evidence has recently shown that a number of cell-derived biophysical and mechanical parameters, among others nucleus stiffness and cell deformability, plays a major role in cell motility, especially in the ameboid-like migration mode in 3D confined tissue structures.
Similar(11)
Mammalian brain development is a complex, ordered process whereby newborn neurons follow stereotyped migration modes to organize into specific patterns required for complicated neural circuit formation.
Although originally studied primarily in two-dimensional in vitro assays, most cell migrations in vivo occur in complex three-dimensional tissue environments that are difficult to recapitulate in cell culture or ex vivo Further, it is now known that cells can mobilize a diverse repertoire of migration modes and subcellular structures to move through and around tissues.
We explored the consequences of altered migration speeds using each of the three migration modes alone.
The conclusions were the same from experiments using the other two migration modes.
Analogues using chemotactic or cell density-based migration modes that could achieve SM-5 were identified.
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