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As opposed to chemotaxis, where cell migration is stimulated by a growth factor gradient, haptokinetic migration reflects the natural ability of the substrate to promote cell movement.
This study aims to clarify, whether 1) CPC are present in regions of macroscopically intact cartilage from human osteoarthritic joints, 2) CPC migration is stimulated by single growth factors and the cocktail of factors released from traumatized cartilage and 3) CPC migration is influenced by cytokines present in traumatized joints.
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Its expansion westward and southward, through diffusion and migration, was stimulated by a shift from bronze- to ironworking.
Migration was stimulated by the addition of bone morphogenic protein-2 (BMP-2) (Sigma) into the media at a final concentration of 0.1 µg/mL.
Migration was stimulated by addition of 3 nM IL-8 to the lower chamber of the transwell.
After decellularization, this substrate was used to assess biological properties of cardiac primitive cells: proliferation and migration were stimulated by biomatrix from normal heart, while both types of biomatrix protected cardiac primitive cells from apoptosis.
> -wrap-foot> growthwth factor We have already demonstrated that migration of iBREC is stimulated by 10 to 100 ng/ml VEGF165 but not by VEGF121, and that VEGF-induced migration is specifically and completely inhibited by 60 μg/ml ranibizumab [ 14].
Neutrophils migrate in response to chemoattractant gradient and chemotactic factors while the migration of lymphocytes is stimulated by specific antigens, mitogens and other non-specific factors produced by lymphocytes [ 50].
This is of relevance as sequential migration of neutrophils is stimulated by TNF-α induced inflammation and can be reduced by inhibition of Interleukin-6 secretion [ 21].
For example, brevican exposed its promigratory attributes after cleavage by members of the ADAMTS protease family [ 44] and glioma migration on laminin is stimulated by binding of glycosaminoglycans [ 45].
The proliferation and migration of pancreatic cancer cells is stimulated by agonists for the Gs-coupled beta-adrenergic receptors and nicotine triggers this response by stimulating the production of their physiological agonists norepinephrine and epinephrine in pancreatic cancer cells [ 9, 20].
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