Sentence examples for migration into brain from inspiring English sources
This suggests that CCL27 may facilitate autoreactive T lymphocyte migration into brain tissue of MS cases, thus promoting brain inflammation.
In addition, under normal conditions, there is a very low rate of leukocyte migration into brain across the cerebral endothelium.
Increased permeability of the blood brain barrier (BBB), as documented in MS cases [ 9– 11], is essential for leukocyte migration into brain tissue.
The addition of PTx to transgenic mice that overexpresses CCL2 in the CNS resulted in leukocyte migration into brain parenchyma along with increased permeability of tracer and MR contrast agent across the endothelium and glia limitans.
It will contribute to brain edema formation (vasogenic edema), it may participate in neuroinflammation by facilitating leukocyte migration into brain, and it will allow the entry of potentially harmful molecules into brain (e.g. prothrombin which is converted to thrombin and may participate in brain injury; see below).
In vivo mouse models of CM have recently implicated MMP dysfunction in disease pathology, although it should be kept in mind that experimental CM presents important differences compared to human CM, such as leukocyte sequestration in cerebral microvessels and subsequent migration into brain parenchyma [ 49].
There was an increase in leukocyte rolling and adhesion, as well as, cell migration into the brain that could contribute to brain inflammation after sepsis [138].
For brain metastasis, blood brain barrier (BBB) disruption with subsequent increased vascular permeability and leucocyte migration into the brain is pivotal.
Tsuchiya, T. et al. Characterization of microglia induced from mouse embryonic stem cells and their migration into the brain parenchyma.
However, no data is available to clarify if application of such agents might not only inhibit migration of autoreactive effector T cells, but might also interfere with Treg migration into MS brain lesions [28].
MCP-1 also seems to be involved in marrow-derived stromal cell migration into ischemic brain (Wang et al., 2002).
