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Furthermore, zDia2 acts cell-autonomously since transplanted zdia2-knockdown cells exhibited low protrusive activity with aberrant migration in wild type host embryos.
As ApoER2 overloading indeed inhibits neuronal migration in wild type cortices, ApoER2 downloading could somehow enhance migration.
This migration defect is observed as early as in 2nd instar eye discs lacking bnl function, earlier than RBG migration in wild types.
This could in part be due to the variable efficacy of RNAi as evidenced by mab-5 RNAi having no effect on PQR migration in wild type.
(A ) A PGC extending filopodia during migration in wild type embryos (Video 1 ), and (B ) in medusa (med NY054 ) mutant embryos lacking Cxcl12a (Video 3 ).
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Our findings provide rare evidence for a significant relationship between body condition and seasonal migration strategy in wild ungulates in relation to a difference in the quality of resources acquired between distinct seasonal ranges.
Instead, Wolbachia would most likely have to spread through genetic drift, or by migration in the wild, to rise above the unstable p2 (mean, lower and upper 95% CI of p2 2.10%, −5.1%, 9.5%).
Wound healing assay showed decreased migration in FTC133-PTEN wild type after HIF-1α inhibitor pretreatment, whereas chetomin did not affect migration rates in the native PTEN null FTC236 cells (Fig. 4D).
Therefore, we next investigated cell migration in the wild-type and mutant CA1.
In contrast to the results in hNPCs, AhR activation reduced migration distance in wild-type mNPCs by 16% ± 5% (1 μM 3-MC), 21% ± 13% (10 μM 3-MC), and 32% ± 10%[100 μM B(a P] compared with solvent controls, whereas migration was comparable with controls after exposure to the AhR antagonist MNF.
Then, we used 2000 pg/embryo dosage to create complete germ cell-depleted gonad model and comparatively traced the existence and migration status of PGCs in wild type (WT) and the dnd-MO injected gynogenetic embryos.
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