We have also examined migration in rat VSMC and although no enhancement was observed with a synthetic Epac agonist, we also could not reproduce our results with regard to the inhibitory effects on human VSMC migration (results not shown).
Studies have shown that genistein treatment can decrease cell migration in rat prostate carcinoma cells in a dose-dependent manner, over the noncytotoxic concentration range of 1 to 10 μM [ 124].
This aPAD is based on a NOAEL of cerebellum Purkinje cell migration in rat embryos after maternal exposure to 5 mg ETU/kg/day (Khera 1973) and includes a total uncertainty factor of 1,000: 100× for inter- and intraspecies variation, 10× for lack of data on developmental neurotoxicity studies.
Interestingly, a SPARC-like factor was shown to have a very particular effect on neuronal cell migration, regulating radial glia-guided neuron migration in the rat cerebral cortex [203].
IGF1-induced migration in dermal rat fibroblasts was markedly reduced as a function of diabetes (↓ 58%) and hypercortisolemia (↓ 47%) (Fig. 4E).
DNA migration showed augmented in rats exposed to contaminated fish and histopathological analyses showed weak but significant leukocyte infiltration.
In fact, as mentioned above, gestational hypothyroxinemia affects the tangential migration of GABAergic neurons in rats (Cuevas et al. 2005).
A major signal for PDE4B is detected at ~95 kDa in mouse heart, and immunoreactive bands of the same migration were found in rat and human tissue.
