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We have also examined migration in rat VSMC and although no enhancement was observed with a synthetic Epac agonist, we also could not reproduce our results with regard to the inhibitory effects on human VSMC migration (results not shown).
Studies have shown that genistein treatment can decrease cell migration in rat prostate carcinoma cells in a dose-dependent manner, over the noncytotoxic concentration range of 1 to 10 μM [ 124].
This aPAD is based on a NOAEL of cerebellum Purkinje cell migration in rat embryos after maternal exposure to 5 mg ETU/kg/day (Khera 1973) and includes a total uncertainty factor of 1,000: 100× for inter- and intraspecies variation, 10× for lack of data on developmental neurotoxicity studies.
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Thus convergent findings support the ongoing study of disruptions in neuronal migration in rats as a putative model to provide insight on human language disability.
We predict that cortical migration in rats under reduced expression of Lis1 and overexpression of DCX will reduce the bipolar migration, in contrast with the normal morphology observed in mice.
From this we make the following predictions: (1) under reduced Lis1 and enhanced DCX expression, we predict a reduced bipolar migration in rats, and (2) under enhanced DCX expression in mice we predict a normal or a higher bipolar migration.
Hager, G., Dodt, H. U., Zieglgänsberger, W. & Liesi, P. Novel forms of neuronal migration in the rat cerebellum.
Interestingly, a SPARC-like factor was shown to have a very particular effect on neuronal cell migration, regulating radial glia-guided neuron migration in the rat cerebral cortex [203].
IGF1-induced migration in dermal rat fibroblasts was markedly reduced as a function of diabetes (↓ 58%) and hypercortisolemia (↓ 47%) (Fig. 4E).
A major signal for PDE4B is detected at ~95 kDa in mouse heart, and immunoreactive bands of the same migration were found in rat and human tissue.
It could effectively inhibit the leukocyte migration promoted by carrageenan in rat.
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