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Surprisingly, the normal B cells showed a significantly greater (p<0.0001) ability to migrate to CXCL12, with respect to both efficacy (4.5+/−1.2% migration in normal vs. 0.85+/−0.48% migration in CLL cells) and potency (∼10 nM in normal vs ∼50 nM in CLL cells) (Figure 2).
The aim of this study was to determine the effect of this IGFBP protease on IGF-induced proliferation and the effect of IGFBP-1 and IGFBP-2 and their proteolytic fragments on migration in normal and high glucose of human dermal fibroblasts (HDF).
This potentially explains why Smad7 preferentially activates Rac1 and promotes migration in normal, but not cancer, epithelial cells.
EphA2 is thought to down-regulate cell growth and migration in normal epithelium [ 21].
Much progress has been made in identifying specific domains that mediate functions such as adhesion and migration in normal and tumour cells [ 16, 17].
Furthermore, rosiglitazone prevents alveolar epithelial mesenchymal transition and also TGFβ-induced stimulation of collagen gene transcription, myofibroblast transdierentiation, and cell migration in normal fibroblasts [ 29].
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Histamine enhances migration in several normal cells, such as eosinophil, dendritic cells, and lung fibroblast 43– 43.
Their high rate of migration in the normal bile duct of the pig suggests the necessity to induce a stricture before placement.
For instance, A2BAR activation might not be associated with cell migration in either normal pregnancy or preeclampsia, because MRS-1754 was unable to block the stimulatory effect of NECA upon cell migration.
PDGF-AA strongly induced a directional migration in both normal and IPF fibroblasts; however, the extent of this response was significantly lower in the case of IPF fibroblasts suggesting a key role for PDGFRα in this response.
Furthermore, bronchoscopic investigation before and during larval pulmonary migration in four normal volunteers who had each received 50 infective N. americanus larvae demonstrated bronchial mucosal erythema and in one case elevated eosinophils in bronchoalveolar lavage fluid [ 26].
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