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(2013) found that while knockdown of PIKfyve or MTMR3 decreased PI5P and migration in cells stimulated to migrate with FGF1, no statistically significant PI5P decrease occurred in unstimulated cells.
Using a B lymphoblast cell model, we previously demonstrated impairment in NRG1α-mediated migration in cells derived from patients with schizophrenia as well as effects of risk alleles in NRG1 and catechol-O-methyltransferase (COMT), a second gene implicated both in schizophrenia susceptibility and in cancer.
In effect, CUL2 migration in cells expressing UBXN7 ΔUIM was similar to untransfected cells.
Growth receptors, when interacting with corresponding ligands, initiate the process of cell cycle progression and migration in cells.
There were no significant differences in speed of migration in cells treated with control or Vav2 siRNA (Fig. 4C).
Non-parametric, Wilcoxon Mann–Whitney exact tests were used to compare effects on cell proliferation, invasion, and migration in cells treated with control or colXI α1 siRNA.
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There is a modest increase in cell migration in cell lines overexpressing miR-30a compared to their controls.
Nonetheless, VT reduced trans-endothelial permeability and tumor cell migration in cell culture.
We previously demonstrated that TRAM-34 is effective in reducing CXCL12-induced GBM migration in cell lines and primary cells obtained from patients.
Epidermal keratinocytes extracted from Map3k1 ΔKD mice have defective Tgf- β, Activin and Activin B-inducedced migration in cell culture plate-based wound healing assays.
The optimized compound 7a3 exhibited the ability to arrest the cell cycle in the G2/M phase, induce cell apoptosis, and inhibit cell migration in tumour cells.
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