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Haeger, A., Wolf, K., Zegers, M. M. & Friedl, P. Collective cell migration: guidance principles and hierarchies.
Slit homolog 3 protein plays an important role as general cell migration guidance molecule, supporting epidermal cell migration [ 14].
Once interneurons have initiated their migration, guidance systems impart directionality to channel them into appropriate migratory routes.
RNA-seq analysis revealed a decreased expression level of several migration guidance molecules in the cKO retinas, including Reelin.
The ECM is not only a static scaffolding for tissue organization but it is involved as well in many regulatory functions like modulation of migration, guidance of axonal growth, synapse formation and cell proliferation.
While these are a subset of key molecular components, they nevertheless represent functional classes of mechanisms implicated in neuronal migration: guidance cues (GABA and the glial fiber), motility regulators (Lis1 and DCX), and stop signals (Reelin).
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Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior.
Introduction: Eph-Ephrin signaling mediates various cellular processes, including vascular permeability, inflammation, angiogenesis, cell migration, axon guidance, fluid homeostasis, and repair after injury.
The Eph/ephrin signaling pathway is involved in a variety of developmental processes including cell migration, axon guidance and tissue boundary formation in vertebrates [49], [50], [51], [52], [53], [54], [55], [56].
These data point to the fact that IKAP deficiency affects the expression of molecules that serve as cues for the proper migration and guidance of neural crest cells to their destinations.
Semaphorins (Sema) are a large family of secreted and membrane-associated proteins that provide environmental cues to mediate diverse developmental processes including neuronal cell migration, axon guidance, vasculogenesis, branching morphogenesis, and cardiac organogenesis [3] [8].
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