However, it is interesting to postulate that unidirectional, downstream migration from the isolated areas could act to partially restore the correlation between genetic and geographic distance.
Some degenerative changes seem necessary before the disc can herniate; indeed, examination of autopsy or surgical specimens suggest that sequestration or herniation results from the migration of isolated, degenerate fragments of nucleus pulposus through pre-existing tears in the annulus fibrosus [ 52].
Nearly a decade later, Panula et al. demonstrated the migration of rat brain endothelial cells from isolated capillaries.
Furthermore, tumor cells with elevated transendothelial migration activity, isolated from breast cancer patients by fine needle aspiration, have spontaneously elevated MenaINV and suppressed Mena 11a expression [ 26].
In 2009, Colombistatin, a disintegrin that inhibited ADP-induced platelet aggregation, human urinary (T24) and skin melanoma (SK-Mel-28) cancer cell adhesion to fibronectin, and cell migration was isolated from the venom of Bothrops colombiensis [ 183].
Although some of the PGCs from neurula stage embryos could also migrate in an under-agarose migration assay, PGCs isolated from embryos at stages 28 30 generally showed higher ability to migrate under this conditions.
Since sialic acid content on a glycoprotein will interfere with the migration of the glycoprotein in SDS-PAGE, one can predict that the migration of THP isolated from the healthy subjects will be different from those of the stone patients.
These waves of migration appear relatively isolated from each other.
17 Platelet-derived growth factors directly induce cell migration of LECs isolated from different species.
Detailed study of migration properties of the tumor-cell exposed MSCs have unraveled increased migration of the MSCs isolated from breast adipose tissues in comparison to the migration of the MSCs derived from abdominal adipose tissue [ 44].
