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Tracheal migration defects were milder in h674mutant embryos although delayed migration of DT cells was apparent (Figure 2F and I).
Migration defects were also observed with this approach.
DTC migration defects were scored in adult animals using differential interference contrast microscopy.
These cell migration defects were potentially caused by defects in cell adhesion mechanisms.
DTC migration defects were inferred from the resulting shape of the gonad arms.
BANCR was identified as a potential regulator of melanoma cell migration as profound migration defects were observed following BANCR depletion.
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We suspect, however, that migration defects are particularly important.
How misregulation of string might contribute to the migration defects is less immediately obvious.
Fz3 −/− embryos also exhibit subtle defects in the migration of monoaminergic neurons (Fenstermaker et al., 2010) and more severe defects in the migration of VIIth cranial nerve neurons (Qu et al., 2010), but, in general, neuronal migration defects are not a prominent feature of the Fz3 −/− phenotype.
PQR migrations defects were weaker (11 16%), with defective cells failing to migrate away from their birthplace and possibly slightly to the anterior, but never to the normal anterior position of AQR as observed in hse-5 (Table 2).
Furthermore, contact between the endocardial and myocardial precursor populations disrupted the epithelial architecture of the myocardial precursors, and thus their medial migration; in embryos depleted of endocardial cells, the myocardial migration defect was partially rescued.
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