In the absence of HSF2, migration defects as well as alterations in gene expression are reduced.
Using morpholino mediated knockdown experiments, we could demonstrate that the absence of MDGA2A leads to migration defects of trigeminal neurons as well as aberrant axonal growth and defasciculation of facial branchiomotor axons.
Talpid 3 chicken embryos also have polycystic kidneys (Yin et al., 2009), a phenotype that is frequently ascribed to a loss of oriented cell division (Happe et al., 2011; Carroll and Yu, 2012), as well as cell migration defects (Bangs et al., 2011), which may also occur due to loss of cell polarity (Happe et al., 2011; Carroll and Yu, 2012).
The onset of the actin defects correlated well with the onset of the migration defects.
Cell-autonomous deletion of GSK-3 reproduced the migration defect and revealed a neuronal morphology defect (the authors argue for dendrite orientation defects), as well as the persistence of the migration defects in postnatal animals.
In a previous genome-wide RNA interference (RNAi) screen for animals with DTC migration defects (Cram et al. 2006) we identified CACN-1 as a well-conserved and novel regulator of cell migration.
3. Pign and Pgap1 mutants show defective AVE migration; Cripto mutations have AVE migration defects (D'Andrea et al., 2008).
Single mutants for each of these genes, as well as ced-10, have been described as having moderately penetrant DTC migration defects (Gumienny et al. 2001; Reddien and Horvitz 2000; Wu and Horvitz 1998).
Reduction in endogenous BTL signaling enhanced the cell migration defects while suppressing the ectopic branching defects.
Finally, Ena rescues hemocyte migration defects caused by activated Dia.
