Sentence examples for migration defects of from inspiring English sources
Indeed, eye abnormalities observed in LS patients have been suggested to be linked to migration defects of lens cells.
Both the mir-34 transgene, maIs387, and the mir-83 transgene, maIs391, rescue the migration defects of their respective single mutant.
mig-13 did not enhance PQR migration defects of sdn-1, indicating that MIG-13 redundancy with SDN-1 is limited to AQR.
Despite this predicted difference in consequences of the two pak-1 alleles, pak-1 (tm403 ) and pak-1 (ok448 ) homozygotes on max-2 -directed RNAi conferred DTC migration defects of similar strength.
Salivary gland migration defects of gyc76C mutant embryos were rescued by expression of wild-type gyc76C specifically in the gland or surrounding mesoderm, whereas invagination defects were rescued primarily by expression in the gland.
We calculated the minimum threshold for migration defects using our negative control data (see Materials and Methods); migration defects of 9% or fewer of the analyzed egg chambers were considered negative hits.
We have identified an intrinsic migration defect of HSCs to CXCL12 as well as increased levels of MMP-9 in the bone marrow of PECAM-1−/− mice, suggesting that factors intrinsic to both the HSC and bone marrow vascular niche account for the increase in circulating progenitor numbers in the blood of PECAM-1−/− mice.
The migration defect of these mutants therefore reflects a defect in the precise pathfinding of the DTCs as they migrate longitudinally along the ventral or dorsal muscle.
Expression of gyc76C WT in just the salivary gland or mesoderm significantly rescued the gland migration defect of gyc76C homozygous embryos (Fig. 1G).
Our finding that DTC expression of mir-34 and mir-83 can rescue the migration defect of their respective mutants supports the hypothesis that the two miRNAs regulate cdc-42 and pat-3 within the DTCs.
Bergmann glia expressing glial fibrillary acidic protein have been previously identified in MLH and were shown to have disorganized radial fibers [ 11] which may be responsible for the migration defect of granule cells.
