These results show that ANO1 overexpression increases cell migration, which could account for the faster wound closure.
Whether this is due to a role for Trol in supporting cell survival and/or relates to mis-migration is unclear because either could account for the phenotype.
These authors further demonstrated that the protein regains its theoretical size when translated in vitro without the machinery dedicated to glycosylation, indicating that the latter post-translational modification could account for the migration shift of the mature proteins on polyacrylamide gels.
Whether or not the slightly more structured surface (towards the cement mantle) of the MB stem could account for the lower migration cannot be determined in this study.
Finally, to determine if VEGF-induced migration could be accounted for, at least in part, by VEGF acting as a mitogen, we examined the effect of VEGF-A stimulation on proliferation of HT29 cells.
Migration early in our solar system's history could account for other oddities, including the small size of Mars and the sparse, disrupted asteroid belt.
FAK signaling has been linked to EC proliferation as well as migration, suggesting that the loss of FAK expression could account for the major phenotypes observed when ERK1/2 are ablated in EC [45], [50].
ANO1 overexpression also stimulates attachment, spreading, detachment and invasion, which could account for its effects on migration.
Given the similar angiogenic defects induced by tmem33 knockdown and SKF-96365 treatment, we examined whether inhibition of SOCE could account for reduced EC number and migration previously observed in tmem33 morphants (Fig. 4f h, and Supplementary Fig. 2).
The MTT cell viability assay was also performed to test whether a difference in cell proliferation could account for the differences in cell migration observed.
