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TsSP-treated cells show a patrolling phenotype and display reduced monocyte adhesion and transendothelial migration capacities in an in vitro model of the BBB.
We found that blockade of CXCR4 pathway by GST-NT21MP decreased SDF-1-induced cell growth, adhesion and migration capacities in breast cancer cells.
Conversely, immortalized mouse mammary fibroblasts from AhR-null mice had decreased migration capacities in culture and inhibition of signaling pathways that regulate cell migration, including focal adhesion kinase and mitogen-activated protein kinase ERK1 (extracellular-signal regulated kinase-1) (Mulero-Navarro et al. 2005).
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We also found that reduction of PTEN expression in these CRC cell lines induced their migration capacity in vitro probably by promoting the activation of Rac and Cdc42.
The result showed that RBP-J deficient EPC had a remarkably reduced migration capacity in response to SDF-1α (Fig. 5B and C).
Enzymatic activity of CK-B was indispensable since cyclocreatine completely blocked the gain in migration capacity in both CK-B expressing cell pools (Figure 6C and D, Video S3) without overt effects on viability or proliferation rate (Figure S1).
The SCAP population also demonstrated an elevated tissue regeneration capacity (Figure 2E), higher telomerase activity than that of DPSCs from the same tooth (Figure 2F), and an improved migration capacity in a scratch assay (Figure 2G), when compared to DPSCs from the same tooth.
In line with this, we observed that HUCPVCs also exhibited greater migration capacity in vivo towards experimental HCC.
The effect of COUP-TFI is mediated by the induction of MAPK signaling and leads to enhanced growth and migration capacity in cancer cells in response to CXCL12.
The aim of our study was to look at the course and the significance of PMN migration capacity in surviving and nonsurviving critically ill patients.
We previously demonstrated that stable expression of GBP-1 in murine endothelial progenitor cells (EPC) induces their premature differentiation and decreases their migration capacity in vitro and in vivo.
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CEO of Professional Science Editing for Scientists @ prosciediting.com