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Mouse chimera and grafting experiments have shown that mixing migration-capable NC cells with a sufficient number of NC cells with genetic lesions in Ret (16), Ednrb (107), or Sox10 (106) impairs migration of wild-type ENCDCs enough to cause distal aganglionosis in chimeric embryos and grafted bowel tissue.
These data demonstrate that VANGL2 is an important part of the chemotactic machinery that is both required for efficient migration and capable to promote chemotaxis when overexpressed.
Taken collectively, these studies suggest that migration of DC capable of effective activation and antigen presentation into breast cancers may be defective and strategies leading to better DC migration may be required also, irrespective of how many potentially effective DC are delivered around the tumour.
Thus while FLN-deficient cells are capable of migration in any given time period they are less likely to initiate migration.
Conclusions Maternal cells enter the fetal circulation and are capable of migration to fetal and neonatal organs.
Therefore, these results could indicate that DC are capable of migration after interacting with Pb.
Each cell was modelled as a non-deformable sphere (20 µm in diameter) governed by a rule set, and cells were capable of migration, proliferation and differentiation.
Collectively, these data show that following a 9 day delayed transplantation, hCNS-SCns are capable of migration in the injured spinal cord.
Overexpression of miR-130b significantly increased the number of cells capable of migration and invasion (P < 0.05).
These progenitors are capable of migration in maternal damaged tissues and can differentiate into various phenotypes [ 10].
In contrast, we confirmed that SP cells were more capable of migration and invasion than MP cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com