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Open image in new window Figure 5 MiR-495 induces breast cancer cell migration by targeting JAM-A.
These results suggested that COP1 might suppress TNBC cell invasion and migration by targeting ETV1.
MiR-720 was described to inhibit breast tumor invasion and migration by targeting the metastasis promoter TWIST1 [ 81].
miR-1 is able to inhibit thyroid carcinoma cell proliferation and migration by targeting CCND2, CXCR4 and CXCL12 [ 60].
Like other miRNAs, miR-146a can modulate cellular activities, such as cell proliferation, differentiation, and migration, by targeting mRNAs encoding specific proteins.
Second, we did not employ an animal model to confirm that COP1 might suppress TNBC cell invasion and migration by targeting ETV1.
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It was a scene whose subtlety encapsulates the problem of dealing with the Mediterranean migration crisis by targeting individual smugglers and their boats.
For example, LAMC1 in the " focal adhesion" pathway has been implicated in processes such as cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis; miR-29a/b regulates this pathway and inhibits cancer cell migration and invasion by targeting LAMC1 [ 44].
In glioblastoma tumors, miR-34a was generally downregulated but when overexpressed, functioned to inhibit glioblastoma cell proliferation, survival, migration and invasion by targeting c-Met and Notch [72], [73].
Knocking-down miR-221 increases LNCaP cell migration and invasion by targeting DVL2 [ 45].
These results demonstrate that magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway.
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