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In addition, studies have demonstrated that continuous ERK activity can regulate invasion and migration by regulating transcription of genes or directly regulating enzymes necessary for cell movement [ 52, 53].
These results indicate that ERM proteins exert a redundant control on PDGF-induced VSMC migration by regulating focal adhesion turn-over and cell adhesion to substrate.
This O-GlcNAc modified HDAC1 further functions in regulating the global histone acetylation level, and therefore influences the cell proliferation, invasion, and migration by regulating target genes in HepG2 cells (Zhu et al., 2016), suggesting the potential coordinative role in hepatic carcinoma.
Furthermore, FILIP, a FLNa-interacting protein, was reported to control neuronal migration by regulating FLNa levels [17], [18].
It appears that podocalyxin may play a role in the control of cell migration by regulating the dynamics of cell protrusion formation and interactions with collagen type 1.
Our results support a model where RhoA/ROCK signaling contributes to T cell polarization and migration by regulating both contractility and MT stability (Figure 10).
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This finding shows that FGFR1 regulates epiblast cell migration by differentially regulating the intercellular adhesion properties of these cells at the primitive streak.
These functions indicate that Snail greatly affects cancer cell migration and metastasis by regulating attachment of tumor cells to basement membranes, degradation of local connective tissue, and penetration and migration of tumor cells through stroma.
Pten is involved in regulating cell migration and invasion by regulating matrix metalloproteinase 2 (MMP2) and MMP9.
Furthermore, we showed that PAK1 can affect RUFY3-mediated gastric cancer cell migration and invasion by regulating its expression.
We had demonstrated that VLDLR II promotes SGC7901 cell migration and invasion by regulating the expression of matrix metalloproteinase 2 (MMP2) and MMP9 [ 21].
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