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Controlled by various myosin light chain kinases [33], these filaments can antagonize cell migration by promoting attachment [35], [38].
Lebret et al (2007) showed that CAFs enhanced migration by promoting EMT of PMC42-LA cells.
Thus golli modulation of VOCCs accelerates cell migration by promoting Ca2+-dependent soma translocation and leading to process formation.
mTORC2 may affect cell migration by promoting PKCα-dependent phosphorylation of the focal adhesion component paxillin [ 20].
Previous comparative analyses of random and directionally persistent migration proposed that high activity of Rac1 favors random migration by promoting peripheral lamellae (Pankov et al, 2005).
Cortactin is an F-actin-binding protein involved in cytoskeletal rearrangements and cell migration by promoting actin-related protein (Arp 2/3 mediated actin polymerization.
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Moreover, EVs were found to carry MMPs that play an important role in angiogenesis by facilitating endothelial cell migration and by promoting activation of angiogenic growth factors and other signaling molecules [ 45].
Neuronal adhesion molecule binding by RPTPζ is thought to influence neuron glial cell interactions and cell migration, e.g. by promoting transcriptional activity of NFκB [ 87] which is implicated in the integration of signals involved in adhesion and migration.
Conclusions: Akt activation plays a critical role in enabling As-transformed HBEC migration and invasion by promoting ZEB1 and ZEB2 expression.
Moreover, we demonstrated that Akt activation drives As-transformed HBEC migration and invasion by promoting the expression of EMT-inducing transcription factors zinc-finger E-box binding homE-box binding1 (ZEB1) and ZEB2.
These data suggest that GDF15 regulates migration and proliferation by promoting EGFR signalling in the perinatal HP and represent a first description of a functional role for GDF15 in the developing telencephalon.
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migration by downloading
migration by destabilizing
migration by affecting
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migration by pressing
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