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In other reports, RKIP promotes cell migration by downregulating E cadherin and upregulating β1 integrin [13], [14].
Mechanistically, PRL-3 promotes cell proliferation and migration by downregulating Csk, leading to Src activation.
The siRNA-mediated PAK4 knockdown elevated anoikis, and inhibited invasion and migration by downregulating MMP-2, αv β3-integrin and phospho-epidermal growth factor receptor (phospho-EGFR).
However, simultaneous depletion of both PAK4 and MMP-2 led to significant anoikis-mediated cell death and severe inhibition in cell migration by downregulating αv β3-mediated EGFR pathway activation.
Taken together, those data suggestted that berberine inhibits C. pneumoniae infection-induced VSMC migration by downregulating the expressions of MMP3 and MMP9 via PI3K [ 32]. Park [ 33] reported that berberine can inhibit Candida krusei with MIC < 1 μg/ml and palmatine can inhibited Candida tropicalis with MIC of 16 μg/ml.
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It inhibited in vitro cell proliferation and migration through Matrigel by downregulating proteolytic cascades.
In the present study, we determined that let-7a suppressed breast cancer cell migration and invasion by downregulating CCR7 expression.
A recent report describes that mir-27b can suppress the directional migration of MSCs by downregulating SDF1 α expression by binding directly to the SDF1 α 3′UTR [ 44].
Based on this hypothesis, it is possible to explain that magnolin inhibited cell migration and invasion by downregulating ERK-mediated Vimentin protein level by downregulating the RSK2-mediated NF-κB signaling pathway.
These results are in accordance with a recent report that describes that mir-27b can suppress the directional migration of MSC by downregulating SDF1α expression by binding indirectly to the SDF1α 3′UTR [ 44].
The miR-720 promotes cell migration of HeLa cells by downregulating Rab35.
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